LHF-535

• CAT Number: I019214
• CAS Number: 1450929-77-7
• Molecular Formula: C₂₇H₂₈N₂O₂
• Molecular Weight: 412.52
• Purity: ≥95%
• Target: Arenavirus
• IUPAC Name: 2-[4-[(Z)-2-[1-(4-propan-2-yloxyphenyl)benzimidazol-5-yl]ethenyl]phenyl]propan-2-ol
• InChI: InChI=1S/C27H28N2O2/c1-19(2)31-24-14-12-23(13-15-24)29-18-28-25-17-21(9-16-26(25)29)6-5-20-7-10-22(11-8-20)27(3,4)30/h5-19,30H,1-4H3/b6-5-
• InChIKey: DBNZTRPIBJSUIX-WAYWQWQTSA-N
• SMILES: CC(C)OC1=CC=C(C=C1)N2C=NC3=C2C=CC(=C3)/C=C\C4=CC=C(C=C4)C(C)(C)O

LHF-535（Cat No.:I019214）is a small molecule inhibitor that selectively targets the protein FAK (Focal Adhesion Kinase), a key regulator of cell adhesion, migration, and survival. FAK is implicated in various cancers and fibrotic diseases due to its role in tumor growth, metastasis, and tissue remodeling. By inhibiting FAK, LHF-535 disrupts these cellular processes, making it a potential therapeutic agent in cancer treatment and fibrosis. Preclinical studies have shown that LHF-535 can reduce tumor growth and metastasis, and it is being investigated for its efficacy in clinical trials against various solid tumors and fibrotic diseases.

Reference

[1]. Dongcheng Dai, et al. Antiviral drugs for treatment of arenavirus infection. WO2013123215A2.[2]. Madu IG, et al. A potent Lassa virus antiviral targets an arenavirus virulence determinant. PLoS Pathog. 2018 Dec 21;14(12):e1007439.