For research use only. Not for therapeutic Use.
LHVS (N-morpholinyl-leucine-homophenylalanine-vinyl sulfone phenyl)（Cat No.:I018013）is a highly selective inhibitor of cathepsin S, a cysteine protease involved in antigen processing within immune cells. By inhibiting cathepsin S, LHVS reduces antigen presentation and is studied for its potential in treating autoimmune diseases and chronic inflammatory conditions. Its specificity to cathepsin S makes it an invaluable tool in immunology research, providing insights into immune modulation and antigen processing pathways. LHVS holds promise in developing new therapeutic approaches for immune-mediated disorders and certain cancers.
| Catalog Number | I018013 |
| CAS Number | 170111-28-1 |
| Molecular Formula | C₂₈H₃₇N₃O₅S |
| Purity | ≥95% |
| Target | Anti-infection |
| Storage | Store at -20°C |
| IUPAC Name | N-[(2S)-1-[[(E,3S)-1-(benzenesulfonyl)-5-phenylpent-1-en-3-yl]amino]-4-methyl-1-oxopentan-2-yl]morpholine-4-carboxamide |
| InChI | InChI=1S/C28H37N3O5S/c1-22(2)21-26(30-28(33)31-16-18-36-19-17-31)27(32)29-24(14-13-23-9-5-3-6-10-23)15-20-37(34,35)25-11-7-4-8-12-25/h3-12,15,20,22,24,26H,13-14,16-19,21H2,1-2H3,(H,29,32)(H,30,33)/b20-15+/t24-,26-/m0/s1 |
| InChIKey | YUMYYTORLYHUFW-MSKIIMLESA-N |
| SMILES | CC(C)C[C@@H](C(=O)N[C@@H](CCC1=CC=CC=C1)/C=C/S(=O)(=O)C2=CC=CC=C2)NC(=O)N3CCOCC3 |
| Reference | [1]. Wilson SR, et al. Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption. J Biol Chem. 2009 Jan 23;284(4):2584-92.<br>[2]. Teo CF, et al.Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion. Antimicrob Agents Chemother. 2007 Feb;51(2):679-88. |
