For research use only. Not for therapeutic Use.
Licochalcone A（Cat No.:I004197）, a flavonoid extracted from the renowned Chinese medicinal herb Glycyrrhiza uralensis Fisch, demonstrates significant anti-cancer effects. This compound has been found to exhibit potent activity against cancer cells. The IC50 value for UGT1A1, an enzyme involved in drug metabolism, is measured at 0.97 μM, indicating its inhibitory potential. Licochalcone A’s anti-cancer properties, coupled with its natural origin, position it as a promising candidate for further research and potential therapeutic applications in cancer treatment.
| Catalog Number | I004197 |
| CAS Number | 58749-22-7 |
| Synonyms | (2E)-3-[5-(1,1-dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one |
| Molecular Formula | C21H22O4 |
| Purity | ≥95% |
| Target | Autophagy |
| Solubility | 10 mg/mL in DMSO |
| Storage | -20°C |
| IUPAC Name | (E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one |
| InChI | InChI=1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+ |
| InChIKey | KAZSKMJFUPEHHW-DHZHZOJOSA-N |
| SMILES | CC(C)(C=C)C1=C(C=C(C(=C1)C=CC(=O)C2=CC=C(C=C2)O)OC)O |
| Reference | </br>1:Licochalcone A Suppresses Specificity Protein 1 as a Novel Target in Human Breast Cancer Cells. Kang TH, Seo JH, Oh H, Yoon G, Chae JI, Shim JH.J Cell Biochem. 2017 May 12. doi: 10.1002/jcb.26131. [Epub ahead of print] PMID: 28498645 </br>2:Antitumor effects and the underlying mechanism of licochalcone A combined with 5-fluorouracil in gastric cancer cells. Lin X, Tian L, Wang L, Li W, Xu Q, Xiao X.Oncol Lett. 2017 Mar;13(3):1695-1701. doi: 10.3892/ol.2017.5614. Epub 2017 Jan 18. PMID: 28454311 Free PMC Article</br>3:Antioxidative and anticancer properties of Licochalcone A from licorice. Chen X, Liu Z, Meng R, Shi C, Guo N.J Ethnopharmacol. 2017 Feb 23;198:331-337. doi: 10.1016/j.jep.2017.01.028. Epub 2017 Jan 19. PMID: 28111219 </br>4:Cytotoxicity of trans-chalcone and licochalcone A against breast cancer cells is due to apoptosis induction and cell cycle arrest. Bortolotto LF, Barbosa FR, Silva G, Bitencourt TA, Beleboni RO, Baek SJ, Marins M, Fachin AL.Biomed Pharmacother. 2017 Jan;85:425-433. doi: 10.1016/j.biopha.2016.11.047. Epub 2016 Nov 27. PMID: 27903423 </br>5:Licochalcone A induces T24 bladder cancer cell apoptosis by increasing intracellular calcium levels. Yang X, Jiang J, Yang X, Han J, Zheng Q.Mol Med Rep. 2016 Jul;14(1):911-9. doi: 10.3892/mmr.2016.5334. Epub 2016 May 24. PMID: 27221781 </br>6:Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells. Tang ZH, Chen X, Wang ZY, Chai K, Wang YF, Xu XH, Wang XW, Lu JH, Wang YT, Chen XP, Lu JJ.Sci Rep. 2016 May 17;6:26241. doi: 10.1038/srep26241. PMID: 27184816 Free PMC Article</br>7:Assessment of the inhibition potential of Licochalcone A against human UDP-glucuronosyltransferases. Xin H, Qi XY, Wu JJ, Wang XX, Li Y, Hong JY, He W, Xu W, Ge GB, Yang L.Food Chem Toxicol. 2016 Apr;90:112-22. doi: 10.1016/j.fct.2016.02.007. Epub 2016 Feb 10. PMID: 26875642 </br>8:Skin compatibility and efficacy of a cosmetic skin care regimen with licochalcone A and 4-t-butylcyclohexanol in patients with rosacea subtype I. Schoelermann AM, Weber TM, Arrowitz C, Rizer RL, Qian K, Babcock M.J Eur Acad Dermatol Venereol. 2016 Feb;30 Suppl 1:21-7. doi: 10.1111/jdv.13531. PMID: 26805419 </br>9:Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A. Sulzberger M, Worthmann AC, Holtzmann U, Buck B, Jung KA, Schoelermann AM, Rippke F, Stäb F, Wenck H, Neufang G, Grönniger E.J Eur Acad Dermatol Venereol. 2016 Feb;30 Suppl 1:9-17. doi: 10.1111/jdv.13529. PMID: 26805417 </br>10:Licochalcone A Induced Suicidal Death of Human Erythrocytes. Egler J, Lang F.Cell Physiol Biochem. 2015;37(5):2060-70. doi: 10.1159/000438565. Epub 2015 Nov 20. PMID: 26584303 Free Article |
