Licochalcone A

• CAT Number: I004197
• CAS Number: 58749-22-7
• Molecular Formula: C21H22O4
• Molecular Weight: 338.40
• Purity: ≥95%
• Synonyms: (2E)-3-[5-(1,1-dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one
• Target: Autophagy
• Solubility: 10 mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: (E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
• InChI: InChI=1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+
• InChIKey: KAZSKMJFUPEHHW-DHZHZOJOSA-N
• SMILES: CC(C)(C=C)C1=C(C=C(C(=C1)C=CC(=O)C2=CC=C(C=C2)O)OC)O

Licochalcone A（Cat No.:I004197）, a flavonoid extracted from the renowned Chinese medicinal herb Glycyrrhiza uralensis Fisch, demonstrates significant anti-cancer effects. This compound has been found to exhibit potent activity against cancer cells. The IC50 value for UGT1A1, an enzyme involved in drug metabolism, is measured at 0.97 μM, indicating its inhibitory potential. Licochalcone A’s anti-cancer properties, coupled with its natural origin, position it as a promising candidate for further research and potential therapeutic applications in cancer treatment.