For research use only. Not for therapeutic Use.
Licofelone (Cat No.: R009348)is a dual-action nonsteroidal anti-inflammatory drug (NSAID) that combines COX (cyclooxygenase) inhibition with 5-lipoxygenase (5-LOX) inhibition. This dual mechanism targets both the inflammatory prostaglandins (via COX inhibition) and leukotrienes (via 5-LOX inhibition), offering a broader approach to reducing inflammation. Licofelone has been studied for conditions like osteoarthritis and rheumatoid arthritis, showing effectiveness in reducing pain and inflammation with potentially fewer gastrointestinal side effects compared to traditional NSAIDs. Ongoing research explores its long-term safety and efficacy in clinical use.
| Catalog Number | R009348 |
| CAS Number | 156897-06-2 |
| Synonyms | 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-?1H-pyrrolizine-5-acetic Acid; ML-3000; |
| Molecular Formula | C23H22ClNO2 |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at -20℃ |
| IUPAC Name | 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid |
| InChI | InChI=1S/C23H22ClNO2/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(16-8-10-17(24)11-9-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27) |
| InChIKey | UAWXGRJVZSAUSZ-UHFFFAOYSA-N |
| SMILES | CC1(CC2=C(C(=C(N2C1)CC(=O)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C |
