Lidocaine Hydrochloride Monohydrate

• CAT Number: I007666
• CAS Number: 73-78-9 (HCl); 6108-05-0 (monohydrate)
• Molecular Formula: C14H25ClN2O2
• Molecular Weight: 288.816
• Purity: ≥95%
• Synonyms: Lidocaine Hydrochloride; LIDOCAINE HCL; Lidothesin; Lignocaine hydrochloride; Xyloneural; Xylocitin;;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrate;hydrochloride
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term , or -20°C for long term.

Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. Originally developed as a local anesthetic, it has properties as a class IB antiarrhythmic, a long-acting membrane stabilizing agent used against ventricular arrhythmia. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacine or prilocaine.

Reference

1:Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 5;152:92-100. doi: 10.1016/j.saa.2015.07.060. Epub 2015 Jul 10. The molecular structure and vibrational, (1)H and (13)C NMR spectra of lidocaine hydrochloride monohydrate.Badawi HM,Förner W,Ali SA, PMID: 26196935 DOI: 10.1016/j.saa.2015.07.060 Abstract: The structure, vibrational and NMR spectra of the local anesthetic drug lidocaine hydrochloride monohydrate salt were investigated by B3LYP/6-311G(∗∗) calculations. The lidocaine·HCl·H2O salt is predicted to have the gauche structure as the predominant form at ambient temperature with NCCN and CNCC torsional angles of 110° and -123° as compared to 10° and -64°, respectively in the base lidocaine. The repulsive interaction between the two N-H bonds destabilized the gauche structure of lidocaine·HCl·H2O salt. The analysis of the observed vibrational spectra is consistent with the presence of the lidocaine salt in only one gauche conformation at room temperature. The (1)H and (13)C NMR spectra of lidocaine·HCl·H2O were interpreted by experimental and DFT calculated chemical shifts of the lidocaine salt. The RMSD between experimental and theoretical (1)H and (13)C chemical shifts for lidocaine·HCl·H2O is 2.32 and 8.21ppm, respectively.Copyright © 2015 Elsevier B.V. All rights reserved.