Lidoflazine

• CAT Number: I011944
• CAS Number: 3416-26-0
• Molecular Formula: C30H35F2N3O
• Molecular Weight: 491.627
• Purity: ≥95%
• Synonyms: Lidoflazine; Ordiflazine; Clinium; Corflazine; Klinium;;2-[4-[4,4-Bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
• Solubility: Soluble in DMSO
• Storage: Store at 0-8 °C
• IUPAC Name: 2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
• InChI: InChI=1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)
• InChIKey: ZBIAKUMOEKILTF-UHFFFAOYSA-N
• SMILES: CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F

Lidoflazine (Cat.No:I011944), is a calcium channel blocker used primarily in veterinary medicine. It acts by blocking calcium influx into cardiac and smooth muscle cells, leading to vasodilation and reduced cardiac contractility. Lidoflazine has been studied for its potential use in treating angina and cardiac arrhythmias, but its use in humans is limited.

Reference

1. Circulation. 1982 Jan;65(1 Pt 2):I27-32.

The pathophysiology of angina pectoris and the effect of lidoflazine.

Gobel FL, Nordstrom LA, Nelson RR, Wang Y.

Angina pectoris results from a deficiency in myocardial oxygen supply. The
rate-pressure product is an important predictor of myocardial oxygen requirements
in patients with ischemic heart disease and in normal persons. The rate-pressure
product at the onset of angina pectoris is reproducible under a variety of
circumstances with a suitable protocol. In some patients, coronary artery spasm
may reduce myocardial blood flow and contribute to the development of angina
pectoris. Lidoflazine is a synthetic drug that appears to be a calcium-entry
blocker and results in symptomatic improvement in patients with angina pectoris.
Lidoflazine reduces the exercising rate-pressure product by its effect on heart
rate and by decreasing systemic vascular resistance. It decreases coronary
vascular resistance and antagonizes processes leading to an increase in coronary
vasomotor tone.