Liensinine Diperchlorate

• CAT Number: I017937
• CAS Number: 5088-90-4
• Molecular Formula: C₃₇H₄₄Cl₂N₂O₁₄
• Molecular Weight: 811.66
• Purity: ≥95%
• Target: Autophagy
• Storage: Store at -20°C
• IUPAC Name: 4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;perchloric acid
• InChI: InChI=1S/C37H42N2O6.2ClHO4/c1-38-14-13-26-20-35(43-4)37(22-29(26)30(38)16-23-6-9-27(40)10-7-23)45-33-18-24(8-11-32(33)41)17-31-28-21-36(44-5)34(42-3)19-25(28)12-15-39(31)2;2*2-1(3,4)5/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3;2*(H,2,3,4,5)/t30-,31-;;/m1../s1
• InChIKey: BGUPXKYVHOSZPY-ZAMYOOMVSA-N
• SMILES: CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)O)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)OC)O)OC.OCl(=O)(=O)=O.OCl(=O)(=O)=O

Liensinine Diperchlorate（Cat No.:I017937） is a significant isoquinoline alkaloid derived from the seed embryo of Nelumbo nucifera Gaertn. It exerts its effects by inhibiting late autophagy/mitophagy, impeding the fusion of autophagosomes with lysosomes. Liensinine Diperchlorate exhibits diverse biological activities, such as anti-arrhythmia, anti-hypertension, anti-pulmonary fibrosis, and relaxation of vascular smooth muscle.

Reference

[1]. Zhou J, et al. A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission. Autophagy. 2015;11(8):1259-79.