For research use only. Not for therapeutic Use.
LIMK-IN-22j (Cat.No:I030808) is a selective inhibitor of LIM kinase (LIMK). LIMK is involved in the regulation of actin cytoskeleton dynamics and plays a role in various cellular processes, including cell migration and invasion. LIMK-IN-22j has shown potential as an anti-cancer agent by inhibiting tumor cell growth and metastasis.
| Catalog Number | I030808 |
| CAS Number | 1116571-01-7 |
| Synonyms | LIMK-IN-22j; LIMK IN 22j; LIMKIN22j; LIMK inhibitor 22j; LIMK inhibitor-22j; |
| Molecular Formula | C20H21BrN8 |
| Purity | 98% |
| Target | TGF-beta/Smad |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (S,Z)-N-(3-Bromophenyl)-N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide |
| InChI | InChI=1S/C20H21BrN8/c1-13-9-23-18-17(13)19(26-12-25-18)28-6-7-29(14(2)10-28)20(24-11-22)27-16-5-3-4-15(21)8-16/h3-5,8-9,12,14H,6-7,10H2,1-2H3,(H,24,27)(H,23,25,26)/t14-/m0/s1 |
| InChIKey | KSECQYDNQYAZMQ-AWEZNQCLSA-N |
| SMILES | CC1=CNC2=NC=NC(N3C[C@H](C)N(/C(NC4=CC=CC(Br)=C4)=NC#N)CC3)=C21 |
| Reference | 1: Wu J, Liu S, Fan Z, Zhang L, Tian Y, Yang R. A novel and selective inhibitor of PKC ζ potently inhibits human breast cancer metastasis in vitro and in mice. Tumour Biol. 2016 Jun;37(6):8391-401. doi: 10.1007/s13277-015-4744-9. Epub 2016 Jan 5. PubMed PMID: 26733166. |
