For research use only. Not for therapeutic Use.
Linaclotide is an peptide agonist of guanylate cyclase 2C that is undergoing clinical trials for use in treating abdominal pain in patients with irritable bowel syndrome (IBS) accompanied by constipation. The drug also has promising outlooks for the treatment of gastroparesis, ulcerative colitis, chronic intestinal pseudo-obstruction (CIPO), and inertia coli as well. (Source: http://en.wikipedia.org/wiki/Linaclotide)
| Catalog Number | I007672 |
| CAS Number | 851199-60-5 (acetate); 851199-59-2(free base). |
| Synonyms | MM-416775; MM 416775; MM416775; MD-1100 acetate; Linaclotide; Linaclotide acetate; Linzess; Constela;2-(32-amino-40-(2-amino-2-oxoethyl)-26-(2-carboxyethyl)-23-(4-hydroxybenzyl)-9-(1-hydroxyethyl)-3-methyl-1,4,7,10,13,22,25,28,31,38,41,47-dodecaoxot |
| Molecular Formula | C59H79N15O21S6 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO. |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| Reference | </br>1:Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention. Weinberg DS, Lin JE, Foster NR, Della/’Zanna G, Umar A, Seisler D, Kraft WK, Kastenberg DM, Katz LC, Limburg PJ, Waldman SA.Cancer Prev Res (Phila). 2017 Apr 10. doi: 10.1158/1940-6207.CAPR-16-0286. [Epub ahead of print] PMID: 28396341 </br>2:Optimizing the Use of Linaclotide in Patients with Constipation-Predominant Irritable Bowel Syndrome: An Expert Consensus Report. Rey E, Mearin F, Alcedo J, Ciriza C, Delgado-Aros S, Freitas T, Mascarenhas M, Mínguez M, Santos J, Serra J.Adv Ther. 2017 Mar;34(3):587-598. doi: 10.1007/s12325-016-0473-8. Epub 2017 Jan 12. Review. PMID: 28083815 Free PMC Article</br>3:Linaclotide — Benefit Assessment According to §35a Social Code Book V [Internet]. Institute for Quality and Efficiency in Health Care.Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2013 Jul 30. PMID: 27905758 Free Books & Documents</br>4:Cost-effectiveness of linaclotide compared to antidepressants in the treatment of irritable bowel syndrome with constipation in Scotland. Fisher M, Walker A, Falqués M, Moya M, Rance M, Taylor D, Lindner L.Eur J Health Econ. 2016 Dec;17(9):1091-1100. Epub 2016 Jan 4. PMID: 26728984 </br>5:Economic Evaluation of Linaclotide for the Treatment of Adult Patients With Chronic Idiopathic Constipation in the United States. Huang H, Taylor DC, Carson RT, Sarocco P, Friedman M, Munsell M, Blum SI, Menzin J.Manag Care. 2016 Feb;25(2):41-8. PMID: 27008836 Free Article</br>6:Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial. Lacy BE, Schey R, Shiff SJ, Lavins BJ, Fox SM, Jia XD, Blakesley RE, Hao X, Cronin JA, Currie MG, Kurtz CB, Johnston JM, Lembo AJ.PLoS One. 2015 Jul 29;10(7):e0134349. doi: 10.1371/journal.pone.0134349. eCollection 2015. PMID: 26222318 Free PMC Article</br>7:MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux. Tchernychev B, Ge P, Kessler MM, Solinga RM, Wachtel D, Tobin JV, Thomas SR, Lunte CE, Fretzen A, Hannig G, Bryant AP, Kurtz CB, Currie MG, Silos-Santiago I.J Pharmacol Exp Ther. 2015 Oct;355(1):48-56. doi: 10.1124/jpet.115.224329. Epub 2015 Jul 27. PMID: 26216942 Free Article</br>8:A comparison of linaclotide and lubiprostone dosing regimens on ion transport responses in human colonic mucosa. Kang SB, Marchelletta RR, Penrose H, Docherty MJ, McCole DF.Pharmacol Res Perspect. 2015 Mar;3(2):e00128. doi: 10.1002/prp2.128. Epub 2015 Mar 13. PMID: 26038704 Free PMC Article</br>9:Comparison of adequate relief with symptom, global, and responder endpoints in linaclotide phase 3 trials in IBS-C. Camilleri M, Lembo AJ, Lavins BJ, MacDougall JE, Carson RT, Williams VS, Nelson LM, Shiff SJ, Currie MG, Kurtz CB, Johnston JM.United European Gastroenterol J. 2015 Feb;3(1):53-62. doi: 10.1177/2050640614555946. PMID: 25653859 Free PMC Article</br>10:Linaclotide. A bacterial enterotoxin derivative with a laxative action, nothing more. [No authors listed]Prescrire Int. 2014 Dec;23(155):285-8. PMID: 25629140 |
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