Linoleic Acid

• CAT Number: R023522
• CAS Number: 60-33-3
• Molecular Formula: C18H32O2
• Molecular Weight: 280.5
• Purity: ≥95%
• Synonyms: (9Z,12Z)-9,12-Octadecadienoic Acid ;?(Z,Z)-;9,12-Octadecadienoic Acid; (9Z,12Z)-9,12-Octadecadienoic Acid; (Z,Z)-9,12-Octadecadienoic Acid; (Z,Z)-9,12-Octadecadienoic Acid; 9-cis,12-cis-Linoleic Acid; 9Z,12Z-Linoleic Acid; 9Z,12Z-Octadecadienoic Acid
• Target: Endogenous Metabolite
• Storage: -20°C
• IUPAC Name: (9Z,12Z)-octadeca-9,12-dienoic acid
• InChI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-
• InChIKey: OYHQOLUKZRVURQ-HZJYTTRNSA-N
• SMILES: CCCCCC=CCC=CCCCCCCCC(=O)O

Linoleic Acid (CAS 60-33-3) is an n-6 polyunsaturated essential fatty acid (PUFA) used as a precursor of arachidonic acid (AA) and various prostaglandins. Linoleic acid may be used to improve the delivery and efficacy of anticancer drugs and in cancer protection.

Reference

1. L. Chuang et al. “Inhibitory effect of conjugated linoleic acid on linoleic acid elongation in transformed yeast with human elongase” Lipids, Vol. 36(10),pp. 1099-1103, 2001
2. M. Wadman et al. “Conversion of linoleic acid into novel oxylipins by the mushroom Agaricus bisporus” Lipids, Vol. 40(11) pp. 1163-1170, 2005
3. P. Elias, B. Brown, V. Ziboh “The Permeability Barrier in Essential Fatty Acid Deficiency: Evidence for a Direct Role for Linoleic Acid in BarrierFunction” Journal of Investigative Dermatology, Vol.74 pp. 230–233, 1980