For research use only. Not for therapeutic Use.
Linopirdine dihydrochloride (CAT: I010490) is a chemical compound that functions as a blocker of KV7 (KCNQ) voltage-gated potassium channels. It is known to selectively block KV7.1 + 7.3 (KCNQ2 + 3) / M-currents with an IC50 ranging from 4 to 7 μM. Additionally, it has an inhibitory effect on KV7.1 (KCNQ1) homomeric channels with an IC50 of approximately 8.9 μM. The ability of linopirdine dihydrochloride to modulate these specific potassium channels makes it a valuable tool for studying neuronal excitability, ion channel function, and potential therapeutic applications related to these channels.
| Catalog Number | I010490 |
| CAS Number | 113168-57-3 |
| Synonyms | Alternative Name: DuP 996 |
| Molecular Formula | C26H23Cl2N3O |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble to 100 mM in water and to 100 mM in DMSO |
| Storage | Desiccate at RT |
| IUPAC Name | 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one;dihydrochloride |
| InChI | InChI=1S/C26H21N3O.2ClH/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22;;/h1-17H,18-19H2;2*1H |
| InChIKey | ZEVVHCGTTNRYOY-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)N2C3=CC=CC=C3C(C2=O)(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl |
