For research use only. Not for therapeutic Use.
Lintitript (CAT: I007674) is a highly potent, selective, orally active, competitive, and non-peptidic cholecystokinin CCK₁ receptor antagonist with a Ki of 0.2 nM and EC₅₀ of 6 nM. It exhibits >33-fold selectivity for CCK₁ over CCK₂ receptors. Lintitript blocks CCK-stimulated amylase release (pA₂ = 7.50) and gallbladder contractions (pA₂ = 9.57), and potently inhibits [¹²⁵I]CCK binding to CCK₁ sites (IC₅₀ = 0.58 nM). In vivo, it completely reverses CCK-induced amylase secretion and inhibits gastric and gallbladder emptying with low ED₅₀ values. Lintitript also increases plasma leptin, insulin, and food intake, making it a valuable tool in gastrointestinal, endocrine, and metabolic research.
| CAS Number | 136381-85-6 |
| Synonyms | 2-[2-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]acetic acid |
| Molecular Formula | C20H14ClN3O3S |
| Purity | ≥95% |
| IUPAC Name | 2-[2-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]acetic acid |
| InChI | InChI=1S/C20H14ClN3O3S/c21-14-7-3-2-6-13(14)15-11-28-20(22-15)23-19(27)17-9-12-5-1-4-8-16(12)24(17)10-18(25)26/h1-9,11H,10H2,(H,25,26)(H,22,23,27) |
| InChIKey | ILNRQFBVVQUOLP-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C=C(N2CC(=O)O)C(=O)NC3=NC(=CS3)C4=CC=CC=C4Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
