Lipofermata

• CAT Number: I019196
• CAS Number: 297180-15-5
• Molecular Formula: C₁₅H₁₀BrN₃OS
• Molecular Weight: 360.23
• Purity: ≥95%
• Target: Bacterial
• IUPAC Name: 5-bromo-5'-phenylspiro[1H-indole-3,2'-3H-1,3,4-thiadiazole]-2-one
• InChI: InChI=1S/C15H10BrN3OS/c16-10-6-7-12-11(8-10)15(14(20)17-12)19-18-13(21-15)9-4-2-1-3-5-9/h1-8,19H,(H,17,20)
• InChIKey: RRBYYBWDUNSVAW-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=NNC3(S2)C4=C(C=CC(=C4)Br)NC3=O

Lipofermata（Cat No.:I019196）is a chemical compound that belongs to the spiro-indoline-thiadiazole analog family and exhibits antibacterial activity inhibited by zinc. It interferes with zinc homeostasis in E.coli K-12, showing a minimum inhibitory concentration (MIC) of 16 μM. Lipofermata’s mechanism of action likely involves disrupting zinc-dependent processes in the bacteria, leading to growth inhibition. Its specific interaction with zinc highlights its potential as a therapeutic agent against zinc-dependent bacterial infections and provides a basis for further exploration in antibacterial drug development.

Reference

[1]. Falconer SB, et al. Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae. ACS Infect Dis. 2015;1(11):533-543.