Lipoic acid

• CAT Number: I000737
• CAS Number: 1200-22-2
• Molecular Formula: C8H14O2S2
• Molecular Weight: 206.33
• Purity: ≥95%
• Target: NF-κB
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IUPAC Name: 5-[(3R)-dithiolan-3-yl]pentanoic acid
• InChI: 1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
• InChIKey: AGBQKNBQESQNJD-SSDOTTSWSA-N
• SMILES: C1CSS[C@@H]1CCCCC(=O)O

Lipoic acid (Cat No.: I000737), also known as α-lipoic acid (ALA), is a naturally occurring antioxidant involved in mitochondrial energy metabolism. It plays a crucial role in redox balance, scavenging free radicals and regenerating other antioxidants like vitamin C and glutathione. ALA has been studied for its neuroprotective, anti-inflammatory, and insulin-sensitizing properties, making it beneficial for diabetes, neurodegenerative diseases, and cardiovascular health. Due to its dual solubility in water and fat, lipoic acid efficiently protects cells from oxidative stress and metabolic dysfunction.

Reference

1:Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone. Oliveira TQ, Sousa CNS, Vasconcelos GS, de Sousa LC, de Oliveira AA, Patrocínio CFV, Medeiros IDS, Honório Júnior JER, Maes M, Macedo D, Vasconcelos SMM.J Affect Disord. 2017 May 11;219:49-57. doi: 10.1016/j.jad.2017.05.022. [Epub ahead of print] PMID: 28521187 2:[Effect of α-lipoic acid on free radical processes in serum of rats on high fat diet]. Cichoń M, Błaszczyk U, Zalejska-Fiolka J.Med Pr. 2017 May 16;68(3):391-399. doi: 10.13075/mp.5893.00533. Epub 2017 Apr 4. Polish. PMID: 28512366 Free Article3:Effect of Lipoic Acid on the Biochemical Mechanisms of Resistance to Bortezomib in SH-SY5Y Neuroblastoma Cells. Tibullo D, Giallongo C, Puglisi F, Tomassoni D, Camiolo G, Cristaldi M, Brundo MV, Anfuso CD, Lupo G, Stampone T, Li Volti G, Amenta F, Avola R, Bramanti V.Mol Neurobiol. 2017 May 11. doi: 10.1007/s12035-017-0575-6. [Epub ahead of print] PMID: 28497200 4:Soft Ultraviolet (UV) Photopatterning and Metallization of Self-Assembled Monolayers (SAMs) Formed from the Lipoic Acid Ester of α-Hydroxy-1-acetylpyrene: The Generality of Acid-Catalyzed Removal of Thiol-on-Gold SAMs using Soft UV Light. Pukenas L, Prompinit P, Nishitha B, Tate DJ, Singh NDP, Wälti C, Evans SD, Bushby RJ.ACS Appl Mater Interfaces. 2017 May 19. doi: 10.1021/acsami.7b04708. [Epub ahead of print] PMID: 28485941 5:POTENTIAL ADMINISTRATION OF LIPOIC ACID AND COENZYME Q AGAINST ADIPOGENSIS: TARGET FOR WEIGHT REDUCTION. Al-Ghamdi MA, Choudhry H, Al-Doghather HA, Huwait EH, Kumosani TA, Moselhy SS.Afr J Tradit Complement Altern Med. 2016 Nov 23;14(1):272-277. doi: 10.21010/ajtcam.v14i1.29. eCollection 2017. PMID: 28480405 6:Impaired Corneal Sensation and Nerve Loss in a Type 2 Rat Model of Chronic Diabetes Is Reversible With Combination Therapy of Menhaden Oil, α-Lipoic Acid, and Enalapril. Davidson EP, Coppey LJ, Shevalye H, Obrosov A, Kardon RH, Yorek MA.Cornea. 2017 Jun;36(6):725-731. doi: 10.1097/ICO.0000000000001182. PMID: 28476051 7:Alpha-lipoic acid: An inimitable feed supplement for poultry nutrition. Sohaib M, Anjum FM, Nasir M, Saeed F, Arshad MS, Hussain S.J Anim Physiol Anim Nutr (Berl). 2017 Apr 26. doi: 10.1111/jpn.12693. [Epub ahead of print] Review. PMID: 28447384 8:Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action. De Cicco S, Immediata V, Romualdi D, Policola C, Tropea A, Di Florio C, Tagliaferri V, Scarinci E, Della Casa S, Lanzone A, Apa R.Gynecol Endocrinol. 2017 Apr 23:1-4. doi: 10.1080/09513590.2017.1313972. [Epub ahead of print] PMID: 28434274 9:Effect of alpha-lipoic acid on endometrial implants in an experimental rat model. Pınar N, Karapınar OS, Özcan O, Özgür T, Bayraktar S.Fundam Clin Pharmacol. 2017 Apr 21. doi: 10.1111/fcp.12293. [Epub ahead of print] PMID: 28429826 10:Determination of lipoic acid in human urine by capillary zone electrophoresis. Kubalczyk P, Głowacki R.Electrophoresis. 2017 Apr 18. doi: 10.1002/elps.201700002. [Epub ahead of print] PMID: 28418619