For research use only. Not for therapeutic Use.
Lipoxin A<sub>4</sub> (LXA<sub>4</sub>) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-<wbr></wbr>HETE or 15-<wbr></wbr>HpETE with human leukocytes. LXA<sub>4</sub> is equipotent to leukotriene B<sub>4</sub> (LTB<sub>4</sub>) in inducing superoxide generation in human neutrophils at 0.1 µM. LXA<sub>4</sub> is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.
| CAS Number | 89663-86-5 |
| Synonyms | LXA4;5(S),6(R),15(S)-TriHETE |
| Molecular Formula | C20H32O5 |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Storage | -80°C |
| IUPAC Name | (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid |
| InChI | InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1 |
| InChIKey | IXAQOQZEOGMIQS-SSQFXEBMSA-N |
| SMILES | CCCCCC(C=CC=CC=CC=CC(C(CCCC(=O)O)O)O)O |
| Reference | 1.Serhan, C.N.,Nicolaou, K.C.,Webber, S.E., et al. Lipoxin A. Stereochemistry and biosynthesis. The Journal of Biological Chemisty 261, 16340-16345 (1986). |
