Lipoxin A4 Lipid Maps® MS Standard

• CAT Number: R016440
• CAS Number: 89663-86-5
• Molecular Formula: C20H32O5
• Molecular Weight: 352.471
• Purity: ≥95%
• Synonyms: LXA4;5(S),6(R),15(S)-TriHETE
• Target: Metabolic Enzyme/Protease
• Storage: -80°C
• IUPAC Name: (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid
• InChI: InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
• InChIKey: IXAQOQZEOGMIQS-SSQFXEBMSA-N
• SMILES: CCCCCC(C=CC=CC=CC=CC(C(CCCC(=O)O)O)O)O

Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM. LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.

Reference

1.Serhan, C.N.,Nicolaou, K.C.,Webber, S.E., et al. Lipoxin A. Stereochemistry and biosynthesis. The Journal of Biological Chemisty 261, 16340-16345 (1986).