For research use only. Not for therapeutic Use.
Liproxstatin-1 (Cat.No:I005643) is a small molecule compound that acts as an inhibitor of lipid peroxidation, a process involved in oxidative stress and cellular damage. It is particularly known for its potential to protect cells from oxidative damage by stabilizing cellular membranes and preventing the degradation of polyunsaturated fatty acids. Liproxstatin-1 has shown promise in preclinical studies for its neuroprotective properties, particularly in neurodegenerative diseases, and its ability to support cell survival by counteracting harmful free radicals. Further research is needed to explore its clinical applications.
| Catalog Number | I005643 |
| CAS Number | 950455-15-9 |
| Synonyms | N-(3-chlorobenzyl)-4/’H-spiro[piperidine-4,3/’-quinoxalin]-2/’-amine |
| Molecular Formula | C19H21ClN4 |
| Purity | ≥95% |
| Target | Ferroptosis |
| Solubility | DMSO: ≥ 36 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | N-[(3-chlorophenyl)methyl]spiro[1,4-dihydroquinoxaline-3,4'-piperidine]-2-imine |
| InChI | InChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23) |
| InChIKey | YAFQFNOUYXZVPZ-UHFFFAOYSA-N |
| SMILES | ClC1=CC(CNC(C2(CCNCC2)N3)=NC4=C3C=CC=C4)=CC=C1 |
| Reference | </br>1:Theoretical insights into the mechanism of ferroptosis suppression via inactivation of a lipid peroxide radical by liproxstatin-1. Sheng X, Shan C, Liu J, Yang J, Sun B, Chen D.Phys Chem Chem Phys. 2017 May 10. doi: 10.1039/c7cp00804j. [Epub ahead of print] PMID: 28489094 </br>2:On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. Zilka O, Shah R, Li B, Friedmann Angeli JP, Griesser M, Conrad M, Pratt DA.ACS Cent Sci. 2017 Mar 22;3(3):232-243. doi: 10.1021/acscentsci.7b00028. Epub 2017 Mar 7. PMID: 28386601 Free PMC Article |
