Liproxstatin-1 (Cat.No:I005643) is a potent and selective inhibitor of ferroptosis, a regulated form of cell death characterized by the accumulation of lipid peroxides. By inhibiting lipid peroxidation, Liproxstatin-1 protects cells from oxidative damage and has shown potential in various disease models, including neurodegenerative disorders and cancer.
| Catalog Number | I005643 |
| CAS Number | 950455-15-9 |
| Synonyms | N-(3-chlorobenzyl)-4/’H-spiro[piperidine-4,3/’-quinoxalin]-2/’-amine |
| Molecular Formula | C19H21ClN4 |
| Purity | ≥95% |
| Target | Ferroptosis |
| Solubility | DMSO: ≥ 36 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | N-[(3-chlorophenyl)methyl]spiro[1,4-dihydroquinoxaline-3,4'-piperidine]-2-imine |
| InChI | InChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23) |
| InChIKey | YAFQFNOUYXZVPZ-UHFFFAOYSA-N |
| SMILES | ClC1=CC(CNC(C2(CCNCC2)N3)=NC4=C3C=CC=C4)=CC=C1 |
| Reference | </br>1:Theoretical insights into the mechanism of ferroptosis suppression via inactivation of a lipid peroxide radical by liproxstatin-1. Sheng X, Shan C, Liu J, Yang J, Sun B, Chen D.Phys Chem Chem Phys. 2017 May 10. doi: 10.1039/c7cp00804j. [Epub ahead of print] PMID: 28489094 </br>2:On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. Zilka O, Shah R, Li B, Friedmann Angeli JP, Griesser M, Conrad M, Pratt DA.ACS Cent Sci. 2017 Mar 22;3(3):232-243. doi: 10.1021/acscentsci.7b00028. Epub 2017 Mar 7. PMID: 28386601 Free PMC Article |
