For research use only. Not for therapeutic Use.
Lirafugratinib hydrochloride（Cat No.:I043417）is a potent and selective inhibitor of fibroblast growth factor receptor (FGFR) kinases, particularly FGFR1-4. It has shown promise in the treatment of cancers driven by FGFR mutations or alterations, such as certain types of bladder, liver, and breast cancers. By inhibiting FGFR signaling, Lirafugratinib hydrochloride can suppress tumor cell proliferation, angiogenesis, and metastasis. This targeted therapy is being investigated in clinical trials for its effectiveness in treating FGFR-driven cancers and may offer a promising treatment option for patients with resistant or advanced cancers.
| CAS Number | 2688040-45-9 |
| Synonyms | N-[4-[4-amino-5-[3-fluoro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-methylpyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-2-methylprop-2-enamide;hydrochloride |
| Molecular Formula | C28H25ClFN7O2 |
| Purity | ≥95% |
| IUPAC Name | N-[4-[4-amino-5-[3-fluoro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-methylpyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-2-methylprop-2-enamide;hydrochloride |
| InChI | InChI=1S/C28H24FN7O2.ClH/c1-15(2)27(37)35-19-8-5-17(6-9-19)24-22(23-25(30)32-14-33-26(23)36(24)4)18-7-10-21(20(29)13-18)38-28-31-12-11-16(3)34-28;/h5-14H,1H2,2-4H3,(H,35,37)(H2,30,32,33);1H |
| InChIKey | HLGJPRBWELSHLI-UHFFFAOYSA-N |
| SMILES | CC1=NC(=NC=C1)OC2=C(C=C(C=C2)C3=C(N(C4=NC=NC(=C34)N)C)C5=CC=C(C=C5)NC(=O)C(=C)C)F.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
