For research use only. Not for therapeutic Use.
Lirafugratinib（Cat No.:I043418）is a selective inhibitor of fibroblast growth factor receptor (FGFR) kinases, particularly targeting FGFR1-4. It is being investigated for its potential in treating cancers associated with FGFR mutations or amplifications, such as bladder, liver, and breast cancers. By inhibiting FGFR signaling, Lirafugratinib interferes with processes critical to tumor growth, angiogenesis, and metastasis. This targeted therapy aims to provide a more effective treatment option for cancers that are resistant to traditional therapies. Clinical trials are underway to assess its efficacy and safety for patients with FGFR-driven cancers.
| CAS Number | 2549174-42-5 |
| Synonyms | N-[4-[4-amino-5-[3-fluoro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-methylpyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-2-methylprop-2-enamide |
| Molecular Formula | C28H24FN7O2 |
| Purity | ≥95% |
| IUPAC Name | N-[4-[4-amino-5-[3-fluoro-4-(4-methylpyrimidin-2-yl)oxyphenyl]-7-methylpyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-2-methylprop-2-enamide |
| InChI | InChI=1S/C28H24FN7O2/c1-15(2)27(37)35-19-8-5-17(6-9-19)24-22(23-25(30)32-14-33-26(23)36(24)4)18-7-10-21(20(29)13-18)38-28-31-12-11-16(3)34-28/h5-14H,1H2,2-4H3,(H,35,37)(H2,30,32,33) |
| InChIKey | XOQVZSSDIQQUGO-UHFFFAOYSA-N |
| SMILES | CC1=NC(=NC=C1)OC2=C(C=C(C=C2)C3=C(N(C4=NC=NC(=C34)N)C)C5=CC=C(C=C5)NC(=O)C(=C)C)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
