For research use only. Not for therapeutic Use.
Lisinopril（Cat No.:I004825） is an angiotensin-converting enzyme (ACE) inhibitor widely prescribed for the treatment of conditions such as hypertension, congestive heart failure, and heart attacks. By inhibiting ACE, lisinopril reduces the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby relaxing blood vessels and lowering blood pressure. It also helps in improving cardiac function and reducing the workload on the heart. Lisinopril is commonly used in combination with other medications and is known for its effectiveness and well-established safety profile in managing cardiovascular conditions.
| Catalog Number | I004825 |
| CAS Number | 76547-98-3 |
| Synonyms | MK-521;MK-522 |
| Molecular Formula | C21H31N3O5 |
| Purity | ≥95% |
| Target | Angiotensin-converting Enzyme (ACE) |
| Solubility | DMSO <1 mg/mL; Water 20 mg/mL |
| Storage | 2-8°C |
| IUPAC Name | (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid |
| InChI | InChI=1S/C21H31N3O5/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29)/t16-,17-,18-/m0/s1 |
| InChIKey | RLAWWYSOJDYHDC-BZSNNMDCSA-N |
| SMILES | C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O |
| Reference | </br>1:Design and characterization of lisinopril-loaded superparamagnetic nanoparticles as a new contrast agent for in vitro, in vivo MRI imaging, diagnose the tumors and drug delivery system. Abbasi Pour S, Shaterian HR.J Mater Sci Mater Med. 2017 Jun;28(6):91. doi: 10.1007/s10856-017-5900-0. Epub 2017 May 11. PMID: 28497361 </br>2:Comparative effectiveness of enalapril, lisinopril and ramipril in the treatment of patients with chronic heart failure. A propensity score matched cohort study. Fröhlich H, Henning F, Täger T, Schellberg D, Grundtvig M, Goode K, Corletto A, Kazmi S, Hole T, Katus HA, Atar D, Cleland JGF, Agewall S, Frankenstein L, Clark AL.Eur Heart J Cardiovasc Pharmacother. 2017 May 5. doi: 10.1093/ehjcvp/pvx013. [Epub ahead of print] PMID: 28475676 </br>3:The effect of swimming exercise on adenine-induced kidney disease in rats, and the influence of curcumin or lisinopril thereon. Ali BH, Karaca T, Al Suleimani Y, Al Za/’abi M, Al Kalbani J, Ashique M, Nemmar A.PLoS One. 2017 Apr 26;12(4):e0176316. doi: 10.1371/journal.pone.0176316. eCollection 2017. PMID: 28445490 Free PMC Article</br>4:Efficacy and safety of twice- vs once-daily dosing of lisinopril for hypertension. Tsai T, Kroehl ME, Smith SM, Thompson AM, Dai IY, Trinkley KE.J Clin Hypertens (Greenwich). 2017 Apr 25. doi: 10.1111/jch.13011. [Epub ahead of print] PMID: 28439946 Free Article</br>5:The Role of Cyclooxygenase Enzymes in the Effects of Losartan and Lisinopril on the Contractions of Rat Thoracic Aorta. Ozatik FY, Kaygisiz B, Erol K.Eurasian J Med. 2017 Feb;49(1):16-21. doi: 10.5152/eurasianjmed.2017.16254. PMID: 28416926 Free PMC Article</br>6:[Effects of Amlodipine/Lisinopril Fixed-Dose Combination on Severity of Left Ventricular Hypertrophy and Parameters of Myocardial Stiffness in Patients With Hypertension]. Ostroumova OD, Kochetkov AI.Kardiologiia. 2016 Dec;56(11):27-37. Russian. PMID: 28290816 </br>7:Effect of angiotensin-converting enzyme inhibitor, lisinopril on morphological and biochemical aspects of fibrotic liver regeneration. Ambreen A, Jahan S, Malik S.Saudi J Gastroenterol. 2016 Nov;22(6):428-434. doi: 10.4103/1319-3767.195559. PMID: 27976638 Free PMC Article</br>8:Haematopoietic effects of Angelica sinensis root cap polysaccharides against lisinopril-induced anaemia in albino rats. Younas F, Aslam B, Muhammad F, Mohsin M, Raza A, Faisal MN, Hassan SU, Majeed W.Pharm Biol. 2017 Dec;55(1):108-113. Epub 2016 Sep 22. PMID: 27925507 </br>9:Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepatotoxicity in rats. Mohammed NE, Messiha BA, Abo-Saif AA.Saudi Pharm J. 2016 Nov;24(6):635-644. Epub 2015 May 19. PMID: 27829805 Free PMC Article</br>10:Evaluation of Certain Pharmaceutical Quality Attributes of Lisinopril Split Tablets. Fahelelbom KM, Al-Tabakha MM, Eissa NA, Javadi J.Sci Pharm. 2016 Oct 11;84(4):646-653. PMID: 27727195 Free PMC Article |
