For research use only. Not for therapeutic Use.
Lisuride maleate（Cat No.:I007677）is a synthetic ergot derivative primarily used as a dopaminergic agent. It acts on dopamine receptors, particularly D2 receptors, to modulate dopamine activity in the brain. Lisuride maleate is commonly used in the treatment of Parkinson’s disease and is sometimes utilized in managing hyperprolactinemia (elevated prolactin levels). It has also been studied for its potential in treating conditions like restless leg syndrome and certain types of migraine. While effective in improving symptoms of these disorders, lisuride maleate may cause side effects such as nausea, dizziness, and dyskinesia, requiring careful monitoring.
| Catalog Number | I007677 |
| CAS Number | 19875-60-6 (maleat); 18016-80-3 (free base). |
| Synonyms | Lisuride Maleate ; Cuvalit; Lysenyl; Lysenyl bimaleate; Lysenyl hydrogen maleate; Lisuride hydrogen maleate; Mesylate, Lisuride; Methylergol ;Carbamide Revanil;;1,1-diethyl-3-(7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinolin-9-yl)urea fumarate |
| Molecular Formula | C24H30N4O5 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | 3-[(6aR,9S)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]-1,1-diethylurea;(Z)-but-2-enedioic acid |
| InChI | InChI=1S/C20H26N4O.C4H4O4/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14;5-3(6)1-2-4(7)8/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,18+;/m0./s1 |
| InChIKey | CVQFAMQDTWVJSV-BAXNFHPCSA-N |
| SMILES | CCN(CC)C(=O)N[C@@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C.C(=C\C(=O)O)\C(=O)O |
| Reference | </br>1:Anticonvulsive effects of the dopamine agonist lisuride maleate after experimental traumatic brain injury. Zweckberger K, Simunovic F, Kiening KL, Unterberg AW, Sakowitz OW.Neurosci Lett. 2010 Feb 12;470(2):150-4. doi: 10.1016/j.neulet.2009.12.075. Epub 2010 Jan 5. PMID: 20056133 </br>2:Symptomatic treatment of premenstrual mastalgia in premenopausal women with lisuride maleate: a double-blind placebo-controlled randomized study. Kaleli S, Aydin Y, Erel CT, Colgar U.Fertil Steril. 2001 Apr;75(4):718-23. PMID: 11287025 </br>3:[Treatment of premenstrual tension syndrome (PMS) with lisuride maleate]. López-Rosales C, Aguilar-Guerrero JA, García-Moreno L.Ginecol Obstet Mex. 1996 Dec;64:556-60. Spanish. PMID: 9019440 </br>4:[Therapeutic effect of lisuride maleate on post-stroke depression]. Hougaku H, Matsumoto M, Hata R, Handa N, Imaizumi M, Sugitani Y, Yoneda S, Etani H, Sueyoshi K, Kusunoki M, et al.Nihon Ronen Igakkai Zasshi. 1994 Jan;31(1):52-9. Japanese. PMID: 8158872 Free Article |
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