Lithium tert-Butoxide

• CAT Number: R033461
• CAS Number: 1907-33-1
• Molecular Formula: C4H9LiO
• Molecular Weight: 80.055
• Purity: ≥95%
• Synonyms: 2-Methyl-2-propanol Lithium Salt; Lithium t-butoxide; Lithium tert-Butanolate;?Lithium tert-Butylate; tert-Butanol Lithium Salt; tert-Butoxylithium
• Storage: -20°C
• IUPAC Name: lithium;2-methylpropan-2-olate
• InChI: InChI=1S/C4H9O.Li/c1-4(2,3)5;/h1-3H3;/q-1;+1
• InChIKey: LZWQNOHZMQIFBX-UHFFFAOYSA-N
• SMILES: [Li+].CC(C)(C)[O-]

Lithium tert-Butoxide(CAT: R033461) is a mild base used in organic synthesis experiments. It can catalyze nucleophilic substitution reactions, such as the preparation of n-alkylation products, and can catalyze reduction reactions, such as the reduction of ketones to alcohols. This product is used in organic synthesis and other scientific research fields.

Reference

1.Liang, Yu-Feng, et al. "Lithium tert-butoxide mediated α-alkylation of ketones with primary alcohols under transition-metal-free conditions." RSC advances 3.21 (2013): 7739-7742.
2.Lee, C. W.; Han, S. J.; Virgil, S. C.; Stoltz, B. M. Stereochemical evaluation of bis(phosphine) copper catalysts for the asymmetric alkylation of 3-bromooxindoles with alpha-arylated malonate esters. Tetrahedron 2015,71 (22), 3666-3670.3.Lou, S.; Ramirez, A.; Conlon, D. A. Catalytic syn-Selective Direct Aldol Reactions of Benzophenone Glycine Imine with Aromatic, Heteroaromatic and Aliphatic Aldehydes. Adv. Synth. Catal. 2015, 357 (1), 28-34.