Lixumistat (IM156)

• CAT Number: I029232
• CAS Number: 1422365-93-2
• Molecular Formula: C13H16F3N5O
• Molecular Weight: 315.29
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: FC(F)(F)OC1=CC=C(NC(=N)NC(=N)N2CCCC2)C=C1

Lixumistat (IM156), is a potent activator of AMPK that increases AMPK phosphorylation. IM156 blocks oxidative phosphorylation (OXPHOS) through the inhibition of complex I and increases apoptosis. IM156 ameliorates various types of fibrosis and inhibits tumors.

Reference

[1] Jimin Son, et al. Immune Netw. 2019 Mar 5;19(2):e11.
[2] Said Izreig, et al. Cell Rep Med. 2020 May 19;1(2):100014.
[3] Kyung Don Ju, et al. Am J Physiol Renal Physiol. 2016 Mar 1;310(5):F342-50.