Lj-1-60

• CAT Number: I047660
• CAS Number: 2414269-68-2
• Molecular Formula: C17H15BrO4
• Molecular Weight: 363.2
• Purity: ≥95%
• IUPAC Name: (E)-3-(4-bromo-3,5-dimethoxyphenyl)-1-(3-hydroxyphenyl)prop-2-en-1-one
• InChI: InChI=1S/C17H15BrO4/c1-21-15-8-11(9-16(22-2)17(15)18)6-7-14(20)12-4-3-5-13(19)10-12/h3-10,19H,1-2H3/b7-6+
• SMILES: COC1=CC(=CC(=C1Br)OC)/C=C/C(=O)C2=CC(=CC=C2)O

Lj-1-60 is an ATP-competitive inhibitor targeting Fyn protein kinase. Lj-1-60 inhibited melanoma proliferation and induced cell cycle arrest into the G2/M phase and apoptosis by targeting Fyn/Stat3 pathway. Lj-1-60 markedly reduced cell viability in a time- and dose-dependent manner, with IC50 values of 1.65 µM (Sk-Mel-5) and 1.36 µM (Sk-Mel-28), respectively. Also, the IC50 value of Lj-1-60 in melanocyte cells PIG1 was 3.9 µM.
KEYWORDS: Lj-1-60 | supplier | Fyn inhibitor | Lj1-60 | Lj 1-60 | CAS [2414269-68-2] | Non Selective | SRC | Inhibitor | Enzymes

Reference

L Tang et al. A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway. Cancer Cell Int. 2020 Jun 18;20:256.