For research use only. Not for therapeutic Use.
L,L-Dityrosine (o,o’-Dityrosine) is a constituent of acid hydrolysates of a number of biological materials, including the insect cuticular resilin[1].
L,L-Dityrosine (o,o’-Dityrosine) is elevated in ventral midbrain and striatum of MPTP-treated mice[2].
| Catalog Number | I018300 |
| CAS Number | 63442-81-9 |
| Synonyms | (2S)-2-amino-3-[3-[5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenyl]-4-hydroxyphenyl]propanoic acid |
| Molecular Formula | C18H20N2O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H20N2O6/c19-13(17(23)24)7-9-1-3-15(21)11(5-9)12-6-10(2-4-16(12)22)8-14(20)18(25)26/h1-6,13-14,21-22H,7-8,19-20H2,(H,23,24)(H,25,26)/t13-,14-/m0/s1 |
| InChIKey | OQALFHMKVSJFRR-KBPBESRZSA-N |
| SMILES | C1=CC(=C(C=C1CC(C(=O)O)N)C2=C(C=CC(=C2)CC(C(=O)O)N)O)O |
| Reference | [1]. Kungl AJ, et al. Molecular dynamics simulation of the rare amino acid LL-dityrosine and a dityrosine-containing peptide: comparison with time-resolved fluorescence. Biochim Biophys Acta. 1994 Dec 15;1201(3):345-52. [2]. S Pennathur, et al. Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o’-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson’s disease. J Biol Chem. 1999 Dec 3;274(49):34621-8. |
