5Z-7-Oxozeaneol（Cat No.:R003072）is a natural compound with antiprotozoal properties. It acts as a potent and irreversible inhibitor of TAK1 (transforming growth factor-beta-activated kinase 1) and VEGF-R2 (vascular endothelial growth factor receptor 2). It exhibits remarkable inhibitory activity against TAK1 and VEGF-R2, with IC50 values of 8 nM and 52 nM, respectively. TAK1 is involved in various cellular processes, including inflammation and cell survival, while VEGF-R2 plays a crucial role in angiogenesis. The selective inhibition of these targets by 5Z-7-Oxozeaneol suggests potential therapeutic applications in diseases related to these pathways.
| Catalog Number | R003072 |
| CAS Number | 253863-19-3 |
| Synonyms | FR148083;L-783,279;LL-Z 1640-2 |
| Molecular Formula | C19H22O7 |
| Purity | ≥95% |
| Storage | 2-8°C |
| IUPAC Name | (4S,6Z,9S,10S,12E)-9,10,18-trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione |
| InChI | InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1 |
| InChIKey | NEQZWEXWOFPKOT-BYRRXHGESA-N |
| SMILES | C[C@H]1C/C=C\C(=O)[C@H]([C@H](C/C=C/C2=C(C(=CC(=C2)OC)O)C(=O)O1)O)O |
| Reference | New zearalenone related macrolides and isocoumarins from an unidentified fungus. Ellestad G. A. et al. , J. Org. Chem. 1978, 43, 2339.<br/><br/>A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J. Ninomiya-Tsuji J. et al. , J. Biol. Chem. 2003, 278, 18485.</span></p> |
