For research use only. Not for therapeutic Use.
LL1 (Cat No.: I030894) is a selective and potent inhibitor designed for cancer and immunology research. It targets key signaling pathways involved in tumor progression, immune modulation, and cellular proliferation. LL1 has demonstrated efficacy in suppressing aberrant cell growth, making it a valuable tool for studying oncogenic mechanisms and therapeutic interventions. Its high specificity and stability enhance its use in preclinical studies for conditions such as leukemia, lymphoma, and solid tumors. LL1 supports drug discovery efforts aimed at novel anticancer and immunotherapeutic strategies.
| Synonyms | LL1; LL 1; LL-1; |
| Molecular Formula | C20H18N4O3S |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 4-((2-(piperazin-1-yl)phenyl)amino)-5H-naphtho[1,8-cd]isothiazol-5-one 1,1-dioxide |
| InChI | InChI=1S/C20H18N4O3S/c25-20-13-4-3-7-18-19(13)15(23-28(18,26)27)12-16(20)22-14-5-1-2-6-17(14)24-10-8-21-9-11-24/h1-7,12,21-22H,8-11H2 |
| InChIKey | XSHDAFOFVMCVAM-UHFFFAOYSA-N |
| SMILES | O=S1(C2=CC=CC(C(C(NC3=CC=CC=C3N4CCNCC4)=C5)=O)=C2C5=N1)=O |
| Reference | 1: Liu Z, Wang H, Guan L, Lai C, Yu W, Lai M. LL1, a novel and highly selective STAT3 inhibitor, displays anti-colorectal cancer activities in vitro and in vivo. Br J Pharmacol. 2020 Jan;177(2):298-313. doi: 10.1111/bph.14863. Epub 2019 Nov 14. PMID: 31499589; PMCID: PMC6989959. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
