For research use only. Not for therapeutic Use.
LM-41 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2. LM-41 inhibits migration of human MDA-MB-231 breast cancer cells[1].
| Catalog Number | I040292 |
| CAS Number | 2996821-30-6 |
| Synonyms | 4-fluoro-2-(3-phenylanilino)benzoic acid |
| Molecular Formula | C19H14FNO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H14FNO2/c20-15-9-10-17(19(22)23)18(12-15)21-16-8-4-7-14(11-16)13-5-2-1-3-6-13/h1-12,21H,(H,22,23) |
| InChIKey | JGUSPMKKPPHSQY-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=CC(=CC=C2)NC3=C(C=CC(=C3)F)C(=O)O |
| Reference | [1]. Ahmed Fnaiche, et al. Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings. Bioorg Med Chem Lett. 2023 Oct 15:95:129488. |
