LM22B-10

• CAT Number: I013178
• CAS Number: 342777-54-2
• Molecular Formula: C₂₇H₃₃ClN₂O₄
• Molecular Weight: 485.01
• Purity: ≥95%
• Target: Protein Tyrosine Kinase/RTK
• Solubility: DMSO: ≥ 150 mg/mL
• IUPAC Name: 2-[4-[[4-[bis(2-hydroxyethyl)amino]phenyl]-(4-chlorophenyl)methyl]-N-(2-hydroxyethyl)anilino]ethanol
• InChI: InChI=1S/C27H33ClN2O4/c28-24-7-1-21(2-8-24)27(22-3-9-25(10-4-22)29(13-17-31)14-18-32)23-5-11-26(12-6-23)30(15-19-33)16-20-34/h1-12,27,31-34H,13-20H2
• InChIKey: QCXQLSGBOUUVNH-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)N(CCO)CCO)C3=CC=C(C=C3)Cl)N(CCO)CCO

LM22B-10(CAT: I013178) is a selective small-molecule activator of the TrkB and TrkC neurotrophin receptors, which play crucial roles in neuronal survival, growth, and synaptic plasticity. By activating these receptors, LM22B-10 stimulates downstream signaling pathways, including the AKT and ERK pathways, both in vitro and in vivo. This activation promotes neuroprotection, neuronal differentiation, and synaptic plasticity, making LM22B-10 a promising compound in neuroscience research for studying neurodegenerative diseases, brain injuries, and mood disorders. Its ability to modulate TrkB/TrkC signaling pathways offers potential for developing novel therapies for conditions such as Alzheimer’s disease, Parkinson’s disease, and depression.