For research use only. Not for therapeutic Use.
LMD-009 is a selective CCR8 nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM[1].
LMD-009 (0-20 nM; 90 min) stimulates inositol phosphate accumulation in COS-7 cells expressing the human CCR8 receptor[1].
LMD-009 (0-100 nM; 1 h) mediates calcium release in Chinese hamster ovary cells[1].
LMD-009 (0.1 nM-100 μM; 40 min) induces L1.2 cells migration[1].
LMD-009 (0-10 μM; 90 min) exhibits different molecular interaction with CCR8 mutations in COS-7 cells[1].
LMD-009 (0-10 nM; 90 min) exhibits no antagonist activity to other human chemokine receptors[1].
| Catalog Number | I018148 |
| CAS Number | 950195-51-4 |
| Synonyms | 8-[[3-(2-methoxyphenoxy)phenyl]methyl]-1-(2-phenylethyl)-1,3,8-triazaspiro[4.5]decan-4-one |
| Molecular Formula | C29H33N3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C29H33N3O3/c1-34-26-12-5-6-13-27(26)35-25-11-7-10-24(20-25)21-31-18-15-29(16-19-31)28(33)30-22-32(29)17-14-23-8-3-2-4-9-23/h2-13,20H,14-19,21-22H2,1H3,(H,30,33) |
| InChIKey | MRXASGVUQJVWMP-UHFFFAOYSA-N |
| SMILES | COC1=CC=CC=C1OC2=CC=CC(=C2)CN3CCC4(CC3)C(=O)NCN4CCC5=CC=CC=C5 |
| Reference | [1]. Jensen PC, et al. Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8. Mol Pharmacol. 2007 Aug;72(2):327-40. |
