LMP7-IN-1

• CAT Number: I019382
• CAS Number: 2285330-15-4
• Molecular Formula: C₁₇H₂₀BNO₅
• Molecular Weight: 329.16
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: [(1R)-2-(1-benzofuran-3-yl)-1-[[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptane-2-carbonyl]amino]ethyl]boronic acid
• InChI: InChI=1S/C17H20BNO5/c20-17(13-8-11-5-6-15(13)24-11)19-16(18(21)22)7-10-9-23-14-4-2-1-3-12(10)14/h1-4,9,11,13,15-16,21-22H,5-8H2,(H,19,20)/t11-,13-,15+,16+/m1/s1
• InChIKey: RFQDLTYXNINJON-OYNZBZHQSA-N
• SMILES: B([C@H](CC1=COC2=CC=CC=C21)NC(=O)[C@@H]3C[C@H]4CC[C@@H]3O4)(O)O

LMP7-IN-1（Cat No.:I019382）is a potent, selective inhibitor of the immunoproteasome subunit LMP7 (β5i), an enzyme crucial in immune cell protein degradation and antigen processing. By inhibiting LMP7, LMP7-IN-1 modulates immune responses, reducing inflammation and cytokine production, which is valuable for treating autoimmune diseases like rheumatoid arthritis and lupus. This specificity minimizes effects on the constitutive proteasome, reducing potential side effects associated with general proteasome inhibitors. LMP7-IN-1 aids research on targeted immunoproteasome inhibition, offering a promising therapeutic approach in autoimmune and inflammatory disorder treatment strategies.

Reference

[1]. Markus Klein, et al. Boronic acid derivatives. WO2019038250A1.