LMTK3-IN-1

• CAT Number: I040787
• CAS Number: 2764850-23-7
• Molecular Formula: C18H11F3N4O
• Molecular Weight: 356.30
• Purity: ≥95%
• Synonyms: 6-pyridin-4-yl-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazine
• InChI: InChI=1S/C18H11F3N4O/c19-18(20,21)26-14-3-1-2-13(10-14)16-11-23-17-5-4-15(24-25(16)17)12-6-8-22-9-7-12/h1-11H
• InChIKey: SFBZOJORTROAIE-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)OC(F)(F)F)C2=CN=C3N2N=C(C=C3)C4=CC=NC=C4

LMTK3-IN-1 (CAT: I040787) is a potent ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) with a binding affinity (Kd) of 2.5 μM. It promotes the degradation of LMTK3 through the ubiquitin-proteasome pathway, effectively suppressing its oncogenic activity. LMTK3-IN-1 exhibits significant anticancer effects across various cancer cell lines and demonstrates strong efficacy in in vivo breast cancer (BC) mouse models. At concentrations of 10–20 μM, it induces apoptosis in BC cell lines, highlighting its potential as a therapeutic candidate. This compound is a valuable tool for studying LMTK3-driven cancer progression and targeted therapy development.