For research use only, not for therapeutic use.
Lobaplatin（Cat No.:M112322）is a platinum-based chemotherapy agent developed as an alternative to cisplatin and carboplatin, aimed at treating various malignancies. It functions by forming DNA cross-links, thereby inhibiting DNA replication and transcription, which leads to cancer cell death. Lobaplatin has demonstrated activity against solid tumors, including lung, ovarian, and testicular cancers, and is often studied for its effectiveness in cisplatin-resistant cases. Its side effects may include myelosuppression, nausea, and neurotoxicity, but it is designed to have a potentially better safety profile compared to traditional platinum compounds.
| Catalog Number | M112322 |
| CAS Number | 135558-11-1 |
| Molecular Formula | C9H18N2O3Pt |
| Purity | ≥95% |
| Storage | -20°C |
| Reference | </br>1:Simple on-line pretreatment of column-switching coupled with ion chromatography for the determination of lactic acid in lobaplatin. Zhao Z, Zhu J, Xie Y.J Pharm Biomed Anal. 2017 May 10;138:316-321. doi: 10.1016/j.jpba.2017.02.031. Epub 2017 Feb 20. PMID: 28242572 </br>2:Safety and efficacy of lobaplatin combined with 5-fluorouracil as first-line induction chemotherapy followed by lobaplatin-radiotherapy in locally advanced nasopharyngeal carcinoma: preliminary results of a prospective phase II trial. Ke LR, Xia WX, Qiu WZ, Huang XJ, Yang J, Yu YH, Liang H, Liu GY, Ye YF, Xiang YQ, Guo X, Lv X.BMC Cancer. 2017 Feb 15;17(1):134. doi: 10.1186/s12885-017-3080-4. PMID: 28202000 Free PMC Article</br>3:Lobaplatin induces BGC-823 human gastric carcinoma cell apoptosis via ROS- mitochondrial apoptotic pathway and impairs cell migration and invasion. Li Y, Liu B, Yang F, Yu Y, Zeng A, Ye T, Yin W, Xie Y, Fu Z, Zhao C.Biomed Pharmacother. 2016 Oct;83:1239-1246. doi: 10.1016/j.biopha.2016.08.053. Epub 2016 Aug 24. PMID: 27565846 </br>4:Re: Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel to treat synchronous peritoneal carcinomatosis from gastric cancer: Results from a Chinese center, Eur J Surg Oncol (2016). Kim JW, Choi SH.Eur J Surg Oncol. 2016 Nov;42(11):1760-1761. doi: 10.1016/j.ejso.2016.06.406. Epub 2016 Aug 11. No abstract available. PMID: 27683051 </br>5:Reply to: Re: Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel to treat synchronous peritoneal carcinomatosis from gastric cancer: Results from a Chinese center, Eur J Surg Oncol (2016). Wu HT, Li Y.Eur J Surg Oncol. 2016 Nov;42(11):1762-1766. doi: 10.1016/j.ejso.2016.06.405. Epub 2016 Aug 12. No abstract available. PMID: 27567099 </br>6:Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel improves survival for patients with peritoneal carcinomatosis from abdominal and pelvic malignancies. Wu HT, Yang XJ, Huang CQ, Sun JH, Ji ZH, Peng KW, Zhang Q, Li Y.World J Surg Oncol. 2016 Sep 15;14(1):246. doi: 10.1186/s12957-016-1004-4. PMID: 27633880 Free PMC Article</br>7:Lobaplatin for the treatment of SK-MES-1 lung squamous cell line in vitro and in vivo. Zhang H, Chen R, Yang S, Liu W, Li K, Zhang H, Zhu X, Chen B.Onco Targets Ther. 2016 Jul 11;9:4215-24. doi: 10.2147/OTT.S108032. eCollection 2016. PMID: 27471396 Free PMC Article</br>8:[Inhibitory effect of imrecoxib combined with lobaplatin on tumor growth and lymph node metastasis of human lung cancer xenografts in nude mice]. Wang DC, Wang LC, Wang LJ, Chen G, Zhao YX, Zhao ZF, Li YH.Zhonghua Zhong Liu Za Zhi. 2016 May 23;38(5):340-5. doi: 10.3760/cma.j.issn.0253-3766.2016.05.004. Chinese. PMID: 27188605 </br>9:Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel to treat synchronous peritoneal carcinomatosis from gastric cancer: Results from a Chinese center. Wu HT, Peng KW, Ji ZH, Sun JH, Zhang Q, Yang XJ, Huang CQ, Li Y.Eur J Surg Oncol. 2016 Jul;42(7):1024-34. doi: 10.1016/j.ejso.2016.04.053. Epub 2016 May 3. PMID: 27179924 Free Article</br>10:An open-label, single-arm phase II clinical study of docetaxel plus lobaplatin for Chinese patients with pulmonary and hepatic metastasis of nasopharyngeal carcinoma. Zhang S, Chen J, Yang S, Lin S.Anticancer Drugs. 2016 Aug;27(7):685-8. doi: 10.1097/CAD.0000000000000370. PMID: 27088576 |
