Lobenzarit

• CAT Number: I030943
• CAS Number: 63329-53-3
• Molecular Formula: C14H10ClNO4
• Molecular Weight: 291.68
• Purity: 98%
• Synonyms: Lobenzarit; Lobenzaritum
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Store at -20°C
• IUPAC Name: 2-((2-carboxyphenyl)amino)-4-chlorobenzoic acid
• InChI: InChI=1S/C14H10ClNO4/c15-8-5-6-10(14(19)20)12(7-8)16-11-4-2-1-3-9(11)13(17)18/h1-7,16H,(H,17,18)(H,19,20)
• InChIKey: UGDPYGKWIHHBMB-UHFFFAOYSA-N
• SMILES: O=C(O)C1=CC=C(Cl)C=C1NC2=CC=CC=C2C(O)=O

Clobenzaril (Cat No.: I030943) is a non-steroidal antipyretic, analgesic and anti-inflammatory drug developed by Chugai Pharmaceutical Co., Ltd., and its chemical name is N-o-carboxyphenyl-4-chloro-2-aminobenzoic acid . It has a regulating effect on the abnormal immune function of the body, and its disodium salt is clinically used to treat chronic rheumatoid arthritis.

Reference

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14: Yamashita Y, Nakano T, Ohsugi Y. New immunomodulator lobenzarit disodium (CCA): activation of IgE class-specific suppressor T lymphocytes and regulation of IgE antibody response enhanced by sublethal X-irradiation in SJL/J mice. Int Arch Allergy Appl Immunol. 1987;83(3):296-302. PubMed PMID: 2954916.
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18: Armesto J, Frutos N, Gonzalez R, Pascual C. In vitro activation of hepatic glutathione reductase from mice by lobenzarit disodium. Agents Actions. 1993 May;39(1-2):69-71. PubMed PMID: 8285143.
19: Kawakami A, Eguchi K, Ueki Y, Migita K, Ida H, Nakao H, Kurata A, Fukuda T, Ishimaru T, Kurouji K, et al. Effects of lobenzarit disodium on human endothelial cells. Lobenzarit disodium inhibits proliferative response, HLA-DR antigen expression, and T cell adherence toward endothelial cells. Arthritis Rheum. 1991 Mar;34(3):296-303. PubMed PMID: 1900689.
20: Takada H, Kishimoto C, Kuroki Y, Matsushita I, Hiraoka Y, Kurokawa M, Ochiai H, Sasayama S. The effects of lobenzarit disodium, a novel immunomodulator, upon murine coxsackievirus B3 myocarditis. Heart Vessels. 1993;8(2):59-66. PubMed PMID: 8390975.