For research use only. Not for therapeutic Use.
LOC14 (CAT: I007683) is a high-affinity protein disulfide isomerase (PDI) modulator. It binds to PDI and modulates its enzymatic activity, impacting protein folding and stability. This makes LOC14 a potential candidate for treating protein-misfolding diseases, including neurodegenerative disorders and certain cancers. By influencing PDI, LOC14 offers therapeutic opportunities in regulating protein homeostasis and addressing related pathologies. Ongoing research aims to elucidate its precise mode of action and expand its potential applications in the field of protein misfolding disorders.
| Catalog Number | I007683 |
| CAS Number | 877963-94-5 |
| Synonyms | LOC14; LOC-14; LOC 14.;2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one |
| Molecular Formula | C16H19N3O2S |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | 2-[[4-(cyclopropanecarbonyl)piperazin-1-yl]methyl]-1,2-benzothiazol-3-one |
| InChI | InChI=1S/C16H19N3O2S/c20-15(12-5-6-12)18-9-7-17(8-10-18)11-19-16(21)13-3-1-2-4-14(13)22-19/h1-4,12H,5-11H2 |
| InChIKey | YVBSNHLFRIVWFQ-UHFFFAOYSA-N |
| SMILES | C1CC1C(=O)N2CCN(CC2)CN3C(=O)C4=CC=CC=C4S3 |
| Reference | </br>1:Kaplan A, Gaschler MM, Dunn DE, Colligan R, Brown LM, Palmer AG 3rd, Lo DC, Stockwell BR. Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2245-52. doi: 10.1073/pnas.1500439112. Epub 2015 Apr 6. PubMed PMID: 25848045; PubMed Central PMCID: PMC4418888.</br>2:Bardiau M, Labrozzo S, Mainil JG. Putative adhesins of enteropathogenic and enterohemorrhagic Escherichia coli of serogroup O26 isolated from humans and cattle. J Clin Microbiol. 2009 Jul;47(7):2090-6. doi: 10.1128/JCM.02048-08. Epub 2009 Apr 29. PubMed PMID: 19403767; PubMed Central PMCID: PMC2708474. |
