For research use only. Not for therapeutic Use.
LockdownPro is an ester-modified variant of Lockdown, which is a potent, selective, cell-active, reversible, and non-competitive PPM1F inhibitor. LockdownPro displayed increased membrane permeability and prodrug-like properties. Importantly, LockdownPro efficiently suppressed tissue invasion of PPM1F-overexpressing human cancer cells in the chicken chorioallantoic membrane tumor assay.
KEYWORDS: LockdownPro | Supplier | PPM1F inhibitor | CAS [2985814-80-8] | Non Selective (Serine-Threonine and Tyrosine Specific Phosphodiesters) | PPM | Inhibitor | Enzymes
| Catalog Number | I047690 |
| CAS Number | 2985814-80-8 |
| Molecular Formula | C39H40O10 |
| Purity | ≥95% |
| Reference | TM Grimm et al. Lockdown, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion. Cell Chem Biol. 2022 Jun 16;29(6):930-946.e9. |
