For research use only. Not for therapeutic Use.
Lodoxamide tromethamine is a medication for the treatment of prophylaxis of mast cell-mediated allergic disease.
| Catalog Number | I013656 |
| CAS Number | 63610-09-3 |
| Molecular Formula | C₁₉H₂₈ClN₅O₁₂ |
| Purity | ≥95% |
| Target | Histamine Receptor |
| Solubility | DMSO: 20 mg/mL |
| IUPAC Name | 2-amino-2-(hydroxymethyl)propane-1,3-diol;2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid |
| InChI | InChI=1S/C11H6ClN3O6.2C4H11NO3/c12-7-5(14-8(16)10(18)19)1-4(3-13)2-6(7)15-9(17)11(20)21;2*5-4(1-6,2-7)3-8/h1-2H,(H,14,16)(H,15,17)(H,18,19)(H,20,21);2*6-8H,1-3,5H2 |
| InChIKey | JJOFNSLZHKIJEV-UHFFFAOYSA-N |
| SMILES | C1=C(C=C(C(=C1NC(=O)C(=O)O)Cl)NC(=O)C(=O)O)C#N.C(C(CO)(CO)N)O.C(C(CO)(CO)N)O |
| Reference | [1]. Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66(4):286-94.<br>[2]. Barr ML, et al. Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar;115(3):631-6; discussion 636-7.<br>[3]. Mann JS, et al. Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study. J Allergy Clin Immunol. 1985 Jul;76(1):83-90. |
