For research use only. Not for therapeutic Use.
Lofexidine-d4 Hydrochloride (Cat No.:C000704) is a deuterium-labeled derivative of lofexidine hydrochloride, a medication used to manage symptoms of opioid withdrawal. Deuterium substitution enhances molecular stability and aids in precise isotopic labeling for research purposes. Lofexidine acts as an alpha-2 adrenergic agonist, mitigating withdrawal symptoms by affecting norepinephrine release.
| Catalog Number | C000704 |
| CAS Number | 1206845-57-9 |
| Synonyms | 2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole-d4 Hydrochloride; MDL-14042A-d4; Ba-168-d4; Britlofex-d4; Lofetensin-d4; Loxacor-d4; |
| Molecular Formula | C₁₁H₉D₄Cl₃N₂O |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Appearance | Off-White to Pale Yellow Solid |
| Storage | -20°C, Hygroscopic |
| IUPAC Name | 4,4,5,5-tetradeuterio-2-[1-(2,6-dichlorophenoxy)ethyl]-1H-imidazole;hydrochloride |
| InChI | InChI=1S/C11H12Cl2N2O.ClH/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13;/h2-4,7H,5-6H2,1H3,(H,14,15);1H/i5D2,6D2; |
| InChIKey | DWWHMKBNNNZGHF-NXMSQKFDSA-N |
| SMILES | CC(C1=NCCN1)OC2=C(C=CC=C2Cl)Cl.Cl |
| Reference | Velly, J., et al.: J. Pharmacol., 8, 351 (1977), Jarrot, B., et al.: Biochem. Pharmacol., 28, 141 (1979), Birch, P., at al.: Brit. J. Pharmacol., 68, 107 (1980), |
