Lofexidine

• CAT Number: I001745
• CAS Number: 31036-80-3
• PubChem Substance ID: 30668
• Molecular Formula: C11H12Cl2N2O
• Molecular Weight: 259.13
• Purity: 98%
• Synonyms: Lofexidine; Lofexidinum
• Target: Neuronal Signaling
• Target Protein: P08913
• Appearance: Solid
• Storage: Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
• IUPAC Name: 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
• InChI: InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15)
• InChIKey: KSMAGQUYOIHWFS-UHFFFAOYSA-N
• SMILES: CC(C1=NCCN1)OC2=C(C=CC=C2Cl)Cl

Lofexidine（Cat No.:I001745）is an alpha-2 adrenergic agonist used to manage withdrawal symptoms in patients undergoing opioid detoxification. It works by reducing the release of norepinephrine, which alleviates symptoms such as anxiety, agitation, sweating, and heart rate increases commonly associated with opioid withdrawal. Unlike opioids, Lofexidine does not have addictive properties, making it a non-narcotic option for easing withdrawal discomfort. Its ability to help patients through the detox process improves adherence to treatment programs, providing a safer, more tolerable method for managing opioid dependence and facilitating recovery.