Loganin

• CAT Number: I002392
• CAS Number: 18524-94-2
• Molecular Formula: C₁₇H₂₆O₁₀
• Molecular Weight: 390.4
• Purity: ≥95%
• Synonyms: NSC 606403;7-hydroxy-6-desoxy Verbenalin
• Target: Apoptosis
• Solubility: 10 mM in DMSO
• Storage: -20°C
• InChI: InChI=1S/C17H26O10/c1-6-9(19)3-7-8(15(23)24-2)5-25-16(11(6)7)27-17-14(22)13(21)12(20)10(4-18)26-17/h5-7,9-14,16-22H,3-4H2,1-2H3/t6-,7+,9-,10+,11+,12+,13-,14+,16-,17-/m0/s1
• InChIKey: AMBQHHVBBHTQBF-UOUCRYGSSA-N
• SMILES: CC1C(CC2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O)O

Loganin (CAT: I002392) is a natural iridoid glycoside derived from various medicinal plants, such as Cornus officinalis and Lonicera japonica. It possesses diverse pharmacological activities and has been studied for its potential therapeutic applications. Loganin exhibits anti-inflammatory, antioxidant, and hepatoprotective properties. It has also demonstrated analgesic effects and the ability to modulate immune responses. Loganin shows promise in the treatment of various conditions, including arthritis, liver diseases, and neurodegenerative disorders. Furthermore, it has been investigated for its anti-cancer potential due to its cytotoxic effects on certain cancer cell lines. Loganin holds potential as a valuable natural compound for drug development and further exploration in the field of medicine.

Reference

[1]. Kim MJ, et al. Loganin protects against pancreatitis by inhibiting NF-κB activation. Eur J Pharmacol. 2015 Oct 15;765:541-50.

[2]. Tsai WH, et al. Ba-Wei-Di-Huang-Wan through its active ingredient loganin counteracts substance P-enhanced NF-κB/ICAM-1 signaling in rats with bladder hyperactivity. Neurourol Urodyn. 2015 Aug 19.