LolCDE-IN-1

• CAT Number: I016345
• CAS Number: 1639933-78-0
• Molecular Formula: C₂₁H₁₆FN₃O
• Molecular Weight: 345.37
• Purity: ≥95%
• Target: Bacterial
• Storage: Store at -20°C
• IUPAC Name: 4-[5-[3-[(4-fluorophenyl)methoxy]phenyl]-1H-pyrazol-4-yl]pyridine
• InChI: InChI=1S/C21H16FN3O/c22-18-6-4-15(5-7-18)14-26-19-3-1-2-17(12-19)21-20(13-24-25-21)16-8-10-23-11-9-16/h1-13H,14H2,(H,24,25)
• InChIKey: DNZHPYAAJMOOPF-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)OCC2=CC=C(C=C2)F)C3=C(C=NN3)C4=CC=NC=C4

LolCDE-IN-1（Cat No.:I016345）is a potent and selective inhibitor targeting the LolCDE complex, a critical component in lipoprotein transport in Gram-negative bacteria. By disrupting this transport system, LolCDE-IN-1 hinders the localization of lipoproteins to the bacterial outer membrane, essential for cell function and survival. This inhibition mechanism makes it a promising candidate for antibiotic development, particularly in combating multidrug-resistant bacterial strains. Research on LolCDE-IN-1 focuses on its potential to address bacterial infections by offering a novel approach that bypasses traditional antibiotic targets, reducing resistance development.