Lomaiviticin A

• CAT Number: I030964
• CAS Number: 349662-86-8
• Molecular Formula: C68H82N6O24
• Molecular Weight: 1367.42
• Purity: 98%
• Synonyms: Lomaiviticin A
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 11-diazo-3-[11-diazo-1-[5-(dimethylamino)-4-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-5,10-dihydroxy-2-(5-hydroxy-4-methoxy-6-methyloxan-2-yl)oxy-4,6,9-trioxo-1,3-dihydrobenzo[b]fluoren-3-yl]-1-[5-(dimethylamino)-4-hydroxy-6-methyloxan-2-yl]oxy-1-ethyl-5,10-dihydroxy-2-(5-hydroxy-4-methoxy-6-methyloxan-2-yl)oxy-2,3-dihydrobenzo[b]fluorene-4,6,9-trione
• InChI: InChI=1S/C68H80N6O24/c1-13-67(97-37-20-32(80)56(74(9)10)24(4)92-37)51-46(45-48(54(51)72-70)62(86)42-30(78)18-16-28(76)40(42)60(45)84)63(87)50(66(67)96-36-21-33(89-11)57(81)25(5)93-36)52-64(88)44-43-47(61(85)41-29(77)17-15-27(75)39(41)59(43)83)53(71-69)49(44)65(95-35-19-31(79)55(73(7)8)23(3)91-35)68(52,14-2)98-38-22-34(90-12)58(82)26(6)94-38/h15-18,23-26,31-38,50,52,55-58,65-66,79-86H,13-14,19-22H2,1-12H3
• InChIKey: IGDPOBULEFXNHY-UHFFFAOYSA-N
• SMILES: CCC1(C(C(=O)C2=C(C1OC3CC(C(C(O3)C)N(C)C)O)C(=[N+]=[N-])C4=C(C5=C(C(=O)C=CC5=O)C(=C24)O)O)C6C(C(C7=C(C6=O)C8=C(C9=C(C(=O)C=CC9=O)C(=C8C7=[N+]=[N-])O)O)(CC)OC1CC(C(C(O1)C)N(C)C)O)OC1CC(C(C(O1)C)O)OC)OC1CC(C(C(O1)C)O)OC

Lomaiviticin A(CAT: I030964) is a potent natural product and DNA-damaging agent derived from marine actinobacteria. It functions by inducing double-strand breaks in DNA, disrupting replication and transcription processes, and exhibiting significant cytotoxic activity. This compound is particularly relevant in the field of oncology, supporting research into novel anticancer therapies. Lomaiviticin A is widely used to study mechanisms of DNA damage and repair, as well as to explore its potential as a chemotherapeutic agent. Its high potency and unique mechanism make Lomaiviticin A a valuable tool in advancing cancer biology and drug discovery research.