Lometrexol disodium

• CAT Number: I007686
• CAS Number: 120408-07-3
• Molecular Formula: C21H23N5Na2O6
• Molecular Weight: 487.42
• Purity: ≥95%
• Synonyms: disodium;(2S)-2-[[4-[2-[(6R)-2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]amino]pentanedioate
• InChI: InChI=1S/C21H25N5O6.2Na/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28;;/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30);;/q;2*+1/p-2/t12-,15+;;/m1../s1
• InChIKey: SVJSWELRJWVPQD-KJWOGLQMSA-L
• SMILES: C1[C@H](CNC2=C1C(=O)NC(=N2)N)CCC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]

Lometrexol disodium（Cat No.:I007686）is a chemotherapy drug that functions as a potent inhibitor of dihydrofolate reductase (DHFR), an enzyme crucial for DNA synthesis. By inhibiting DHFR, Lometrexol disodium disrupts the production of nucleotides, impairing the ability of cancer cells to replicate and proliferate. It is used in the treatment of certain cancers, including hematologic malignancies and solid tumors. Lometrexol disodium is considered an alternative to methotrexate, with potential advantages in overcoming resistance. Its use is being explored in combination therapies to enhance the efficacy of cancer treatments.