For research use only. Not for therapeutic Use.
Lomibuvir（Cat No.:I007687）is a small molecule inhibitor of the hepatitis C virus (HCV) NS5B polymerase, an enzyme essential for viral RNA replication. By inhibiting this polymerase, lomibuvir prevents the replication of the virus, thus reducing viral load in infected individuals. It has been studied as part of combination therapies for chronic hepatitis C, especially in cases resistant to other treatments. Although it showed promise in clinical trials, its development has been limited due to the emergence of more effective direct-acting antivirals for HCV. Lomibuvir is no longer a key player in the treatment of hepatitis C.
| Catalog Number | I007687 |
| CAS Number | 1026785-55-6 (or 1026785-59-0) |
| Synonyms | VX-222; VX222; VX 222; VCH-222; VCH222; VCH 222; VX-22; VX22; VX 22; Lomibuvir;5-(3,3-dimethylbut-1-yn-1-yl)-3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexane-1-carboxamido)thiophene-2-carboxylic acid |
| Molecular Formula | C25H35NO4S |
| Purity | ≥95% |
| Target | Anti-infection |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | 5-(3,3-dimethylbut-1-ynyl)-3-[(4-hydroxycyclohexyl)-(4-methylcyclohexanecarbonyl)amino]thiophene-2-carboxylic acid |
| InChI | InChI=1S/C25H35NO4S/c1-16-5-7-17(8-6-16)23(28)26(18-9-11-19(27)12-10-18)21-15-20(13-14-25(2,3)4)31-22(21)24(29)30/h15-19,27H,5-12H2,1-4H3,(H,29,30) |
| InChIKey | WPMJNLCLKAKMLA-UHFFFAOYSA-N |
| SMILES | CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O |
| Reference | </br> 1:Gentile I, Buonomo AR, Zappulo E, Borgia G. Discontinued drugs in 2012 – 2013: hepatitis C virus infection. Expert Opin Investig Drugs. 2015 Feb;24(2):239-51. doi: 10.1517/13543784.2015.982274. Epub 2014 Nov 11. PubMed PMID: 25384989.</br> 2: Eltahla AA, Tay E, Douglas MW, White PA. Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb binders. Antimicrob Agents Chemother. 2014 Dec;58(12):7215-24. doi: 10.1128/AAC.03699-14. Epub 2014 Sep 22. PubMed PMID: 25246395; PubMed Central PMCID: PMC4249545. |
