Lomibuvir (VX-222)

• CAT Number: I000172
• CAS Number: 1026785-59-0
• Molecular Formula: C25H35NO4S
• Molecular Weight: 445.61
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O

Lomibuvir (VX-222, VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. Phase 2.

Reference

[1] Bedard J, et al. J Hepatol, 2009, 50(Suppl 1), S340.
[2] Yi G, et al. Antimicrob Agents Chemother, 2012, 56(2), 830-837.
[3] Chauret N, et al. J Hepatol, 2009, 50(Suppl 1), S341-S342.