Lomitapide

• CAT Number: A000126
• CAS Number: 182431-12-5
• Molecular Formula: C₃₉H₃₇F₆N₃O₂
• Molecular Weight: 693.72
• Purity: ≥95%
• Synonyms: 182431-12-5; Juxtapid; Lojuxta; BMS-201038; AEGR 733
• Target: MTP inhibitor
• Storage: -20°C
• InChI: InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
• InChIKey: MBBCVAKAJPKAKM-UHFFFAOYSA-N
• SMILES: C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F

Lomitapide is a MTP inhibitor. Lomitapid is a novel agent for the treatment of homozygous familial hypercholesterolemia. Lomitapide is an orally active inhibitor of microsomal triglyceride transfer protein that is indicated as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available for the reduction of LDL-C, total cholesterol, apolipoprotein B, and non-high-density lipoprotein cholesterol in adult patients with HoFH.

Reference

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