Lomitapide Mesylate

• CAT Number: A000119
• CAS Number: 202914-84-9
• Molecular Formula: C40H41F6N3O5S
• Molecular Weight: 789.83
• Purity: ≥95%
• Target: Microsomal Triglyceride Transfer Protein (MTP)
• Storage: Store at -20°C

Lomitapide Mesylate is a lipid-lowering agent used in the treatment of homozygous familial hypercholesterolemia (HoFH), a rare genetic disorder characterized by extremely high cholesterol levels. It works by inhibiting microsomal triglyceride transfer protein (MTP), reducing the production of lipoproteins like very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) in the liver and intestines. This action results in significantly lower plasma cholesterol levels, helping to prevent cardiovascular complications associated with HoFH. Lomitapide Mesylate is typically prescribed alongside a low-fat diet and other lipid-lowering treatments. Due to its potential for hepatotoxicity, regular monitoring of liver function is required during therapy.