For research use only. Not for therapeutic Use.
Lonapalene (RS4317) is a topically effective 5-lipoxygenase (5-LO) inhibitor.
Lonapalene (RS4317) may be useful in the treatment of psoriasis, and that leukotriene B4 is a relevant mediator of the pathology of this disease[1].
| Catalog Number | I013344 |
| CAS Number | 91431-42-4 |
| Synonyms | (4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate |
| Molecular Formula | C16H15ClO6 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H15ClO6/c1-8(18)22-13-11-6-5-10(17)7-12(11)14(23-9(2)19)16(21-4)15(13)20-3/h5-7H,1-4H3 |
| InChIKey | IFWMVQUGSGWCRP-UHFFFAOYSA-N |
| SMILES | CC(=O)OC1=C(C(=C(C2=C1C=CC(=C2)Cl)OC(=O)C)OC)OC |
| Reference | [1]. Black AK, et al. Pharmacologic and clinical effects of lonapalene (RS 43179), a 5-lipoxygenase inhibitor, in psoriasis. J Invest Dermatol. 1990 Jul;95(1):50-4. |
