LONP1-IN-2

• CAT Number: I041715
• CAS Number: 2729981-17-1
• Molecular Formula: C16H27BN4O4
• Molecular Weight: 350.22
• Purity: ≥95%
• Synonyms: [(1R)-3-methyl-1-[[(2R)-2-(pyrazine-2-carbonylamino)hexanoyl]amino]butyl]boronic acid
• InChI: InChI=1S/C16H27BN4O4/c1-4-5-6-12(20-16(23)13-10-18-7-8-19-13)15(22)21-14(17(24)25)9-11(2)3/h7-8,10-12,14,24-25H,4-6,9H2,1-3H3,(H,20,23)(H,21,22)/t12-,14+/m1/s1
• InChIKey: UYJROBYUUYPCNR-OCCSQVGLSA-N
• SMILES: B(C(CC(C)C)NC(=O)C(CCCC)NC(=O)C1=NC=CN=C1)(O)O

LONP1-IN-2 (compound 9d) is a potent and selective LONP1 inhibitor with IC50 values of 0.187 μM and >10 μM for LONP1 and 20S proteasome, respectively. LONP1-IN-2 can be used in research of cancer[1].

Reference

[1]. Kingsley LJ, et, al. Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology. J Med Chem. 2021 Apr 22;64(8):4857-4869.
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