Loperamide Hydrochloride（Cat No.:A000269）is an over-the-counter antidiarrheal medication that works by slowing down gut motility. It acts on the opioid receptors in the intestinal wall, reducing the frequency of bowel movements and increasing the absorption of fluids and electrolytes. Loperamide is used to treat acute diarrhea, including traveler’s diarrhea, and chronic diarrhea associated with conditions like irritable bowel syndrome (IBS). It is generally well-tolerated, with minimal central nervous system effects due to its poor ability to cross the blood-brain barrier, making it a safe and effective option for diarrhea management.
| Catalog Number | A000269 |
| CAS Number | 34552-83-5 |
| Synonyms | 34552-83-5; Loperamide HCl; Imodium; Dissenten; Fortasec |
| Molecular Formula | C29H34Cl2N2O2 |
| Purity | ≥95% |
| Target | Opiate Agonist |
| Storage | -20°C |
| IUPAC Name | 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide;hydrochloride |
| InChI | InChI=1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H |
| InChIKey | PGYPOBZJRVSMDS-UHFFFAOYSA-N |
| SMILES | CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl |
| Reference | 1: Regan RC, Gogal RM Jr, Barber JP, Tuckfield RC, Howerth EW, Lawrence JA. 2: Elqudaby HM, Mohamed GG, El-Din GM. Analytical studies on the charge transfer <br> <br> 5: Brüning J, Podgorski D, Alig E, Bats JW, Schmidt MU. Antidiarrhetic loperamide 6: Yu JH, Kim HJ, Lee S, Hwang SJ, Kim W, Moon CJ. LC-MS determination and <br> 8: Ruddy DA, Sherma J. Determination of the active ingredient loperamide 9: El Sherif ZA, Mohamed AO, Walash MI, Tarras FM. Spectrophotometric 10: Mboya SA, Bhargava HN. Adsorption and desorption of loperamide hydrochloride |
