Lopinavir

• CAT Number: A000587
• CAS Number: 192725-17-0
• Molecular Formula: C37H48N4O5
• Molecular Weight: 628.81
• Purity: ≥95%
• Synonyms: Aluviran; ABT-378; 192725-17-0; ABT 378; Koletra
• Target: HIV Protease
• Solubility: >31.5mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
• InChI: InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
• InChIKey: KJHKTHWMRKYKJE-SUGCFTRWSA-N
• SMILES: CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O

Lopinavir（Cat No.:A000587）is an antiretroviral medication used in combination with ritonavir to treat HIV-1 infection. It works by inhibiting the HIV protease enzyme, preventing the maturation of viral particles and reducing the viral load in the body. The combination with ritonavir enhances lopinavir’s efficacy by inhibiting its metabolism, increasing its plasma levels. Lopinavir/ritonavir is effective in improving immune function and delaying the progression of HIV to AIDS. Common side effects include gastrointestinal disturbances and elevated cholesterol levels. Lopinavir is a crucial component in the management of HIV, enhancing patient outcomes and quality of life.